Research Work

Next Generation Sequencing

NGS refers to a number of high-throughput sequencing technologies that allow researchers to sequence DNA and RNA much more quickly and cheaply than older technologies (i.e. Sanger sequencing). NGS has revolutionized the study of genomics by helping to characterize the genetic markers associated with diseases. The technology has the potential to transform clinical care by driving drug development that can target those makers. Oncology has been at the forefront of this transformation, as NGS has allowed for rapid and detailed testing of individual patient tumors, enabling doctors to tailor therapies based on their patient’s specific risk and sensitivity profiles.
We offer research in Next generation, high-throughput sequencing and data analyses includes Whole Genome Sequencing of Humans, Plants, Animals, Bacteria, Viruses and Chloroplast, Whole Exome Sequencing, Total RNA, mRNA, Amplicon Sequencing.

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Precision Medicine

Clay Christiansen has described precision medicine as disruptive in its ability to drive down health care costs without compromising quality or outcomes. While precision medicine as a health care strategy continues to evolve with early areas of impact on “the triple aim,” significant challenges stand in the way of its fully disruptive potential. In Lahore Medical Research Center (LMRC), we explore the current state of precision medicine, its growing ecosystem and the opportunities that lie ahead for health care and research.
Precision medicine is poised to have an impact on patients, health care delivery systems and research participants in ways that were only imagined 15 years ago when the human genome was first sequenced. While discovery using genome-based technologies has accelerated, these have only begun to be adopted into clinical medicine.

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Forensic DNA Typing And Population Genetics

LMRC intends to work on advanced forensic science and source attribution solutions through innovative efforts. Research in Forensic Sciences includes Mixture deconvolution – resolution of individual DNA profiles in complex mixtures Portable, rapid DNA analysis – validated human identification analysis Featured Research and Development Efforts STRs, MiniSTRs, SNPs Analysis, Ancestry Informative Markers (AIMs) Complex mixture resolution Stronger likelihood ratios for DNA profiles Deep kinship analysis and stronger paternity index Geo-sourcing Eco mapping Predictive genomics Externally-visible Characteristics (ie eye and hair color)(EVCs) Biogeographical ancestry Populations Migrations Phylogeny Analysis Data Analysis using different Softwares like GeneMapper, IDX, Mendeley

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Identification Of Drug Resistance Biomarkers

Scientific Working Group on Molecular Biology (seminar picture) Lahore Medical Research Center (LMRC), Scientific Working Group on Molecular Biology intend to provide full support in all molecular biology procedures, such as DNA extraction (Organic Method/ Commercially available kit Method) Polymerase Chain Reaction (PCR), Real-Time PCR, Qf-PCR, Polyacrylamide Gel Electrophoresis, Gel electrophoresis (horizontal, vertical), Size Estimation of DNA Fragment, Nanodrop, UV-visible spectrophotometry (range: 200-1000 nm), Fluorometric enzyme assays, fluorescence-based assays, AlphaImager Protein Simple (Gel documentation system) (chemiluminescence, DNA quantification, bacterial colony counting, protein gel documentation), Southern and Western Blotting, Primer designing, Sanger sequencing, Phylogenetic studies, Evolutionary studies (evolutionary analysis, Y-Micro deletion Fragment Analysis, Genetics analysis/genotyping, Molecular marker development, High Resolution Melt (HRM) analysis (detects mutations/variations in DNA/RNA samples, Plasmid Preparation etc.

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Genetics Tests

Genes are DNA instructions that we all inherit from our parents. Different “mistakes” in our genes, called mutations, can cause different diseases. Some of these diseases are rare, like cystic fibrosis or Huntington’s disease, others are common, like cancer. Genetic tests can be used to confirm the diagnosis or give you information about possible development of a disease.

  • PCR
  • DNA Sequencing
  • Cytogenetics (Karyotyping and FISH)
  • Microarrays
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Cytology

Aside from tissue biopsy, cytology serves as an indispensable tool in screening and diagnosing cancer. In this technique, a cytological material is obtained from the patient, spread onto glass slides for microscopic examination, stained, screened for abnormalities and assessed prior to the issuance of a final report.

  • Gynaecological Cytology
  • Non-Gynaecological Cytology
  • Fine Needle Aspiration Cytology
  • BAL Differential Cell Count
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Molecular Testing & Oncology

Our comprehensive and highly sensitive and specific range of tests can detect genetic alterations that drive tumor growth in all types of cancer. We are highly experienced in characterizing mechanisms of action of targeted therapies, particularly against epidermal growth factor receptor (EGFR), as well as other tyrosine kinase inhibitors. We perform:

  • Mutation analysis in tumor tissue and blood
  • Gene amplification and translocation testing
  • Immunohistochemistry (IHC)
  • Gene expression
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Histology

Our SANAS accredited histology laboratory offers a diagnostic service to both the private and public sectors. Our large team of anatomical pathologists, technologists and technicians, with vast amounts of experience offers a diagnostic and consultative service on a number of tissue samples including biopsies and resection specimens.

  • Immunocytochemistry
  • Immunofluorescence
  • Electron Microscopy
  • Neuropathology
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General Diagnostic Tests

We are an industry leader in ensuring exceptional quality testing in our state-of-the-art facilities. Diagnostic tests are used to detect, confirm, or rule out the presence of a disease or medical condition. They can be used to screen for certain conditions in people who are at increased risk; to evaluate the effects of treatment; or to monitor disease progression.

  • Complete blood counts
  • Anticoagulant Therapy Monitoring
  • Blood Chemistry Analyses
  • Therapeutic drug monitoring
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Naturopathic Tests

We will perform both standard and specialized naturopathic lab tests as part of the assessment process. Naturopathic doctors can order many of the same diagnostic tests as your family physician, such as blood work, stool, urine, and saliva testing. We can also perform an H Pylori Breath Test, Stool Ova and Parasite testing.

  • Gastrointestinal Testing
  • Laboratory Tests on Hormonal Levels
  • Cardiovascular Lab Tests
  • Toxins & Pollutant Testing
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Genetics Tests

Genes are DNA instructions that we all inherit from our parents. Different “mistakes” in our genes, called mutations, can cause different diseases. Some of these diseases are rare, like cystic fibrosis or Huntington’s disease, others are common, like cancer. Genetic tests can be used to confirm the diagnosis or give you information about possible development of a disease.

  • PCR
  • DNA Sequencing
  • Cytogenetics (Karyotyping and FISH)
  • Microarrays
order test

Cytology

Aside from tissue biopsy, cytology serves as an indispensable tool in screening and diagnosing cancer. In this technique, a cytological material is obtained from the patient, spread onto glass slides for microscopic examination, stained, screened for abnormalities and assessed prior to the issuance of a final report.

  • Gynaecological Cytology
  • Non-Gynaecological Cytology
  • Fine Needle Aspiration Cytology
  • BAL Differential Cell Count
order test
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