Latest Publications

Santomauro DF, Miller PA, Shadid J, Hanson SW, Vo A, Roy DJ, Hagins H, Herrera AM, Scott JG, Erskine HE, McGrath JJ. Updated trends in the global prevalence and burden of mental disorders, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023. The Lancet. 2026 May 23;407(10543):2040-64. doi: 10.1016/S0140-6736(26)00519-2

Sánchez ML, Mehboob R, Coveñas R. Targeting Peptidergic Systems for Melanoma Treatment. Cancers (Basel). 2026 Apr 23;18(9):1347. doi: 10.3390/cancers18091347

Khalid S, Bashir S, Mehboob R, Waseem H, Shahid I, Alzahrani AR, Mazhar Z, Alharazy S. Effects of magnesium and potassium on insulin resistance and blood sugar level among insomniac patients with diabetes mellitus—A randomized controlled trial. J Investig Med. 2026;10815589251378179. doi: 10.1177/10815589251378179

Sirota SB, Bender RG, Dominguez RM, Movo A, Swetschinski LR, Araki DT, Han C, Wool EE, He J, Carter A, Jabbar AA. Global burden of lower respiratory infections and aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023. The Lancet Infectious Diseases. 2026 Apr 1;26(4):343-61. doi: 10.1016/S1473-3099(25)00689-9

GBD 2023 Mental Disorder Collaborators. Updated trends in the global prevalence and burden of mental disorders, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023. Lancet. 2026 May 23;407(10543):2040-2064. doi: 10.1016/S0140-6736(26)00519-2

Alkhotani A, Kabli A, Jastaniah Z, Amjad R, Altoukhi H, Almarzouki H, Alamoudi H, Bokhari R, Shalabi H, Mirdad DS, Mehboob R. Temozolomide as a salvage therapy in aggressive pituitary adenomas and pituitary carcinomas: a systematic review and meta-analysis. Oncologie. 2026 May. doi: 10.1515/oncologie-2026-0038

Khalid S, Bashir S, Mehboob R, Waseem H, Shahid I, Alzahrani AR, Malik U, Shalabi H, Bima AI, Maidin SS, Arif RH, Alim HM. Comparison of Diabetic Nephropathy Markers in Diabetic Patients With Insomnia Before and After Potassium and Magnesium Supplementation: A Randomized Controlled Trial. Health Sci Rep. 2026 Jan 18;9(1):e71738. doi: 10.1002/hsr2.71738

Mehboob R, Shahid I, Alzahrani AR, Yousof SM, Adnan H, Ekram SN, Alwazzan A, Nasief H, Khadawardi KA. Diagnostic and Therapeutic Potential of Substance P/NK1 Receptor in Primary Dysmenorrhea: A Pilot Study. Health Sci Rep. 2026 Jan 18;9(1):e71744. doi: 10.1002/hsr2.71744

GBD 2023 Child Growth Failure Collaborators. Quantifying the fatal and non-fatal burden of disease associated with child growth failure, 2000-2023: a systematic analysis from the Global Burden of Disease Study 2023. Lancet Child Adolesc Health. 2026 Jan;10(1):22-38. doi: 10.1016/S2352-4642(25)00303-7

GBD 2021 US CNS Cancer Collaborators. Burden of Central Nervous System Cancer in the United States, 1990-2021. JAMA Neurol. 2025 Nov 3:e254286. doi: 10.1001/jamaneurol.2025.4286

GBD 2023 Cancer Collaborators. The global, regional, and national burden of cancer, 1990-2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023. Lancet. 2025 Oct 11;406(10512):1565-1586. doi: 10.1016/S0140-6736(25)01635-6

GBD 2023 Cardiovascular Disease Collaborators. Global, Regional, and National Burden of Cardiovascular Diseases and Risk Factors in 204 Countries and Territories, 1990-2023. J Am Coll Cardiol. 2025 Sep 24:S0735-1097(25)07428-5. doi: 10.1016/j.jacc.2025.08.015

GBD 2023 Causes of Death Collaborators. Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023. Lancet. 2025 Oct 18;406(10513):1811-1872. doi: 10.1016/S0140-6736(25)01917-8

GBD 2023 Demographics Collaborators. Global age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950-2023: a demographic analysis for the Global Burden of Disease Study 2023. Lancet. 2025 Oct 18;406(10513):1731-1810. doi: 10.1016/S0140-6736(25)01330-3

GBD 2021 Adult BMI Collaborators. Global, regional, and national prevalence of adult overweight and obesity, 1990-2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021. Lancet. 2025 Mar 8;405(10481):813-838. doi: 10.1016/S0140-6736(25)00355-1

Bamaga A, Kurdi M, Alkhotani A, Alghefari H, Gasemaltayeb R, Mrair F, Fadel ZT, Mehboob R, Tayyib A, Abuzinadah AR. Inflammatory myopathy with abundant macrophage [IMAM]: Systemic analysis and pathological approach to distinguish it from dermatomyositis. J Neuromuscul Dis. 2025 Jan-Feb;12(1):22143602251315376

Khan A, Rafi U, Mehboob R, Hameed S, Malik U, Zubair Z, Shahid I. Serum transferrin level in type-2 diabetic patients in association with sociodemographic profile and dietary habits. Italian Journal of Medicine. 2025 Feb;19(1):1873

Alanazi IA, Mehboob R, Tariq A, Hameed S, Malik U, Sarwar N, Shahid I, Mehboob K. First evidence of immunomodulation of the renin-angiotensin system through substance P/neurokinin 1 receptor: a case and control study in hypertension and cardiac patients. Italian Journal of Medicine. 2025 Feb;19(1):1870

Mehboob K, Ali M, Hassan N, Mehboob Z, Mushtaq MF, Ullah RH, Zahid Akhtar M, Tariq MA, Parveen K, Mehboob R. Exploring the landscape of entrepreneurship in Pakistan: a comparative analysis of perceptions, challenges, and the need for psychoeducational interventions in the academic sector. Frontiers in Education. 2025 Feb 6;10:1516734. doi: 10.3389/feduc.2025.1516734

Khalid S, Bashir S, Basharat S, Mehboob R, Anwar T, Hashim M, Orfali R, Hussain SA, Gilkaramenthi R, Jibreel EA, Asdaq SM. Association of Cholesterol with Hepatorenal Markers and Quality of Life in Diabetic Patients Before and after Magnesium and Potassium Supplements. Saudi Pharmaceutical Journal. 2023 Dec;31(12):101865. doi: 10.1016/j.jsps.2023.101865

Khalid S, Bashir S, Mehboob R, Anwar T, Riaz A, Siddiqi MF, Nadeem A, Malik U, Ali SZ, Shahid I, Basharat S. Frequency of Anxiety and Depression among Diabetic Patients and Their Association with Hepatorenal Biomarkers. Journal of Hunan University (Natural Sciences). 2023 Oct;50(10):145-153. doi: 10.55463/issn.1674-2974.50.10.14

Mehboob R, Ahmad FJ, Qayyum A, Rana MA, Gilani SA, Tariq MA, Tamur S, Shahid I, Mirza IM, Fathaddim A, Abusikkuen SA, Zayed MA. Neurokinin 1 receptor antagonist along with dexamethasone reduces the inflammation in COVID-19 patients: a novel therapeutic approach. Advancements in Life Sciences. 2023 Sep;10(3):1-8

Kurdi M, Fadul MM, Alkhayyat S, Sabbagh A, Alsinani T, Alkhotani A, Mulla N, Mehboob R, Fathaddin AA, Bamaga A, Faizo E, Baeesa S. The synergistic effect of IDH mutation and NDRG-2 dysregulation in the progression of WHO-grade 4 astrocytomas. Pathology - Research and Practice. 2023;248:154733. doi: 10.1016/j.prp.2023.154733

Mehboob R, von Kries JP, Oehme P, Ehsan K, Almansouri M, Bamaga AK. Role of endothelial cells and Angiotensin Converting Enzyme-II in COVID-19 and brain damages post-infection. Frontiers in Neurology - Neuroinfectious diseases. 2023 Jun;14:1210194. doi: 10.3389/fneur.2023.1210194

Lavezzi AM, Mehboob R, Piscioli F, Pusiol T. Involvement of the superior colliculus in SIDS pathogenesis. Biomedicines. 2023 Jun;11(6):1689. doi: 10.3390/biomedicines11061689

Mehboob R, Ahmad FJ, Waseem H, Hassan A, Ehsan K, Malibary H, Tamur S, Kurdi M. Associations between HLA allele frequencies and the development and/or severity of COVID-19. Bioscience Research. 2023 Jun;20(2):586-595

Mehboob R, Oehme P, Pfaff G. On the role of substance P in the respiratory tract in corona infections to the causes of corona-related brain destruction. Leibniz Online. 2023 Mar;48:1-15

Mehboob R, Oehme P, Pfaff G. The role of Substance P in the defense line of the respiratory tract and neurological manifestations post COVID-19 infection. Frontiers in Neurology - Neuroinfectious diseases. 2023 Mar;14:1052811. doi: 10.3389/fneur.2023.1052811

Khalid S, Bashir S, Basharat S, Mehboob R, Aftab MM, Alwazzan A, Riaz A, Shahid I. Comparison of Magnesium versus Potassium and their Combined Effect on Insomnia, Sleep Hormones, Insulin Resistance and Quality of Life among Patients with Diabetes Mellitus. Journal of Hunan University of Natural Sciences. 2023 Feb;50(2):254-259. doi: 10.55463/issn.1674-2974.50.2.27

Mehboob R. Antibiotic Resistance: An upcoming Pandemic. Pakistan Journal of Health Sciences. 2022 Nov 30:01-.

Mohamed F , Mehboob R , Ahmedah HT , Fadl-Elmula I, Alsaqafi AT. Is there an association between IDH1 Mutation, MGMTpromoter Methylation and Neurotrophic Kinase receptor expression in the development and progression of CNS tumours? Bioscience Research. 2022; 19(3): 1498-1503

Mehboob R. Hidden Hunger, its causes and impact on Human life. Pakistan Journal of Health Sciences. 2022 Sep 30:01-.

Mubeen B, Hasnain A, Mehboob R, Rasool R, Riaz A, Elaskary SA, Shah MM, Faridi TA, Ullah I. Hydroponics and elicitation, a combined approach to enhance the production of designer secondary medicinal metabolites in Silybum marianum. Frontiers in Plant Science. 2022;13.

Mehboob R. Eating Disorders: Eating Disorders. DIET FACTOR (Journal of Nutritional & Food Sciences). 2022 Jun 30:01-.

Kurdi M, Katib Y, Faizo E, Bahakeem B, Alkhotani A, Alkhayyat S, Najjar AA, Mehboob R, Halawa TF, Addas BM, Albriky K. Association Between CD204-Expressed Tumor-Associated Macrophages and MGMT-Promoter Methylation in the Microenvironment of Grade 4 Astrocytomas. World Journal of Oncology. 2022 May 10;13(3):117-25.

Mehboob R. Importance of Iron Metabolism: Importance of Iron Metabolism. Pakistan BioMedical Journal. 2022 Mar 30:01-.

Al-Jifree HM, Alwazza AB, Bin SM, Azab AM, Mehboob R. Survival Rates of Epithelial Ovarian Cancer Patients in Western Saudi Arabia: A Single-Center Study. 2022; 19(1): 358-362.

Mehboob R, Ahmad FJ, Mumtaz SU, Khalid S, Waseem H, Abaidullah S, Atwah AF, Abusikkien SA, Nasief H, Bahassan OM, Halwani M. Does Bacillus Calmette-Guerin vaccination protects from COVID-19? A Uni-center Study. Bioscience Research. 2022:426-30.

Mehboob R. Role of Epigenetic alterations in the development of cancers. Pakistan BioMedical Journal. 2022 Feb 28:01-.

Kurdi M, Mehboob R, Baeesa SS, Maghrabi Y, Hakamy S, Alkhotani A, et al., Histomolecular Criteria to Differentiate Grade II/III Ependymoma with Aid of H3K27me3 and L1CAM Expression. Bioscience Research. 2022 Feb; 19(1): 295-304.

Abbas A, Hasnain A, Malik S, Kausar H, Siddiqui MF, Mehboob R, Chaudhry S. Comparison of the Antibacterial Activities of Different Antibiotics Against Clinical Isolates: Antibiotic Resistance Patterns. Pakistan BioMedical Journal. 2022 Jan 31:49-53.

Mehboob R, Kurdi M, Baeesa S, Halawa TF, Tanvir I, Maghrabi Y, Hakamy S, Saeedi R, Moshref R, Nasief H, Hassan A. Immunolocalization of neurokinin 1 receptor in WHO grade 4 astrocytomas, oral squamous cell and urothelial carcinoma. Folia Neuropathologica. 2022 Jan 1;60(2):165-76.

Hassan A, Mehboob R, Tanvir I, Malibary H, Addas BM, Rayes AO, Bano F, Bahassan OM, Alwazzan A. Reverse Genetic Analysis of NS2 Mutational Diversity in Hepatitis C Virus. Journal of Hunan University Natural Sciences. 2022;49(2).

Mehboob R. Greetings for New Year!. Pakistan BioMedical Journal. 2022 Jan 31:1-.

Mehboob R. Antibiotic Resistance in Present Era. MARKHOR (The Journal of Zoology). 2021 Dec 31:01-.

MEHBOOB R, KURDI M, TANVIR I, HASSAN A, BANO F, RAYES AO, BAJOUH O, HASNAIN A. Comparison of Substance P Immunolocalization among Oral, Breast, Colorectal and Endometrial Carcinoma to Evaluate its Prognostic and Therapeutic Significance. PJMHS. 2021 Dec; 15(12): 1-5.

LAVEZZI AM, MEHBOOB R, KURDI M, TANVIR I, BAMAGA AK, NASIEF H, MALIBARY H. Anatomopathological changes of the autonomic nervous system controlling the respiratory rhythm in sudden infant death: advances over the last 30 years.

MEHBOOB R, KURDI M, BAEESA S, BAHAKEEM B, ALKHAYYAT S, MAGHRABI Y, BARDEESI A, SAEEDI R, ASHGHAR M, HAKAMY S, MALIBARY H. The Expression of Sodium Channel Alpha Subunit (Nav1. 7) Receptors in Intracranial Meningioma and Its Comparison to Urothelial, Prostate and Ovarian Cancers.

Mehboob R, Kurdi M, Bamaga A, Aldardeir N, Nasief H, Moshref LH, Alsinani T, Rayes AO, Jabbad RH. Substance P/Neurokinin-1 Receptor, Trigeminal Ganglion, Latency, and Coronavirus Infection-Is There Any Link?. Frontiers in medicine. 2021 Nov 18;8:727593.

Lavezzi AM, Mehboob R. The mesencephalic periaqueductal gray, a further structure involved in breathing failure underlying Sudden Infant Death Syndrome. ASN neuro. 2021 Oct;13:17590914211048260.

Mehboob R, Lavezzi AM. Neuropathological explanation of minimal COVID-19 infection rate in newborns, infants and children–a mystery so far. New insight into the role of Substance P. Journal of the Neurological Sciences. 2021 Jan 15;420:117276.

Mehboob R, Kurdi M, Ahmad M, Gilani SA, Khalid S, Nasief H, Mirdad A, Malibary H, Hakamy S, Hassan A, Alaifan M. Comprehensive analysis of genes associated with sudden infant death syndrome. Frontiers in Pediatrics. 2021:1095.

Mehboob R. Neurokinin-1 receptor as a potential drug target for COVID-19 treatment. Biomedicine & Pharmacotherapy. 2021 Nov 1;143:112159.

Safdar M, Zeb A, Khalid S, Bashir S, Mehboob R, Imran M. Effect of Fortified Wheat Flour on Anemia Status of Adolescent Hostel Girls. Age (years). 2021;21:2-76.

Mehboob R, Hassan S, Gilani SA, Hassan A, Tanvir I, Waseem H, Hanif A. Enhanced neurokinin-1 receptor expression is associated with human dental pulp inflammation and pain severity. Biomed Research International. 2021 May 5;2021:1-7.

Mehboob R, Marchenkova A, van den Maagdenberg AM, Nistri A. Overexpressed Na V 1.7 Channels Confer Hyperexcitability to in vitro Trigeminal Sensory Neurons of Ca V 2.1 Mutant Hemiplegic Migraine Mice. Frontiers in cellular neuroscience. 2021 May 25;15:640709.

Mehboob R, Gilani SA, Hassan A, Tanvir I, Javaid S, Khalid S, Hasan S, Waseem H, Alwazzan A, Munoz M. Prognostic significance of substance P/neurokinin 1 receptor and its association with hormonal receptors in breast carcinoma. BioMed Research International. 2020 Jun 28;2021.

Hassan A, Tanvir I, Mehboob R, Gillani SA, Ahmed FJ, Akram MA . Immunoreactivity of Thyroid Transcription Factor-1 for Diagnosis of Primary Breast Carcinoma. Internal Medicine.2020; 1(1): 28-34.

Mehboob R, Ahmad FJ, Gilani SA, Hassan A, Khalid S, Akram J. Maternal mortality Ratio in low income developing countries-focusing on Pakistan. Preprints. 2020.

Alwazzan A, Mehboob R, Hassan A, Perveen S, Gilani SA, Ahmad FJ, Tanvir I, Babar ME, Tariq MA, Ali G, Akram SJ. Elevated neurokinin-1 receptor expression in uterine products of conception is associated with first trimester miscarriages. Frontiers in Physiology. 2020 Dec 18;11:554766.

Mehboob R, Gilani SA, Hassan A, Tirmazi AH, Ahmad FJ, Akram J. Elevated Neurokinin 1-Receptor Expression in uterine products of conception is associated with first trimester Miscarriages. bioRxiv. 2020 Jun 29:2020-06.

Alwazzan A, Mehboob R, Gilani SA, Hassan A, Perveen S, Tanvir I, Waseem H, Ehsan K, Ahmad FJ, Akram J. Immunohistochemical expression of the alpha nicotinic acetylcholine receptor 7 in the human normal, diabetic, and Preeclamptic placenta and products of conception. Frontiers in Physiology. 2020 Nov 25;11:607239.

Lavezzi AM, Mehboob R, Alfonsi G, Ferrero S. Substantia nigra abnormalities provide new insight on the neural mechanisms underlying the sleep-arousal phase dysfunctions in sudden infant death syndrome. ASN neuro. 2020 Sep;12:1759091420962695.

Mehboob R, Ahmad FJ, Qayyum A, Rana MA, Gilani SA, Tariq MA, Akram J. Aprepitant as a combinant with Dexamethasone reduces the inflammation via Neurokinin 1 Receptor Antagonism in severe to critical Covid-19 patients and potentiates respiratory recovery: A novel therapeutic approach. MedRxiv. 2020 Aug 4:2020-08.

Kabir M, Mehboob R, Gilani SA, Ahmad FJ. Diagnosis and Treatment of Cytokine Storming as a Management of COVID-19 Infection. Annals of King Edward Medical University. 2020 Jul 11;26(Special Issue):214-7.

Gilani SA, Imran M, Haq IU, Mehboob R, Fatima W, Hassan A. Gambogic Acid as Anticancer Agent: A Review. Preprints. 2020.

Mehboob R, Kabir M, Gilani SA, Ahmad FJ. Future Impacts of COVID-19 Infection on Pakistani Population. Annals of King Edward Medical University. 2020 Jul 9;26(Special Issue):107-8.

Zaidi N, Gilani S, Mehboob R, Waseem H, Hassan A. Diagnostic accuracy of carotid intima media thickness by B-mode ultrasonography in coronary artery disease patients. Archives of Medical Science-Atherosclerotic Diseases. 2020 May 27;5(1):79-84.

Akram J, Khan AS, Khan HA, Gilani SA, Akram SJ, Ahmad FJ, Mehboob R. Extensively drug-resistant (XDR) typhoid: evolution, prevention, and its management. BioMed Research International. 2020 May 2;2020.

Khalid S, Fatima A, Aslam M, Waseem H, Mehboob R, Farooq S, Rizwan B. Comparison of Menstrual Pain among Dysmenorrhea and Non-Dysmenorrhea University Students. Lahore Garrison University Journal of Life Sciences. 2020 Nov 11;4(04):300-8.

Ahmad A, Ashraf S, Mehboob R. Current Status of Neurology and Neuroscience Research in Pakistan. Annals of King Edward Medical University. 2017 Dec 5;23(3).

Lavezzi AM, Johanson CE. New approaches to the pathogenesis of sudden intrauterine unexplained death and sudden infant death syndrome. Frontiers in Neurology. 2017 Aug 28;8:441.

Mehboob R, Kabir M, Ahmed N, Ahmad FJ. Towards better understanding of the pathogenesis of neuronal respiratory network in sudden perinatal death. Frontiers in neurology. 2017 Jul 6;8:320.

Ahmed N, Linardi D, Ahmed S, Mehboob R, Luciani GB, Faggian G, Rungatscher A. 233 Anti-arrhythmic role of sphingosine 1-phospahte in post-operative atrial fibrillation by pak1 activation. Heart. 2017 Jun 1;103(Suppl 5):A149-50.

LIKE DP. 168 Cardioprotective role of fingolimod in ischemia-reperfusion injury by activation of akt/erk pathways in rat model. Heart. 2017;103(5):A1-62.

Ahmed N, Linardi D, Decimo I, Mehboob R, Gebrie MA, Innamorati G, Luciani GB, Faggian G, Rungatscher A. Characterization and expression of sphingosine 1-phosphate receptors in human and rat heart. Frontiers in pharmacology. 2017 May 24;8:312.

Mehboob R. Substance P/neurokinin 1 and trigeminal system: a possible link to the pathogenesis in sudden perinatal deaths. Frontiers in neurology. 2017 Mar 13;8:82.

Sadia H, Malik K, Wahid B, Abbas M, Batool Z, Khan MY, Ullah S, Shafi A, Nawaz TN, Mahboob R. Management of Non-Small cell Lung Cancer by genetic studies: A. Bull. Env. Pharmacol. Life Sci. 2016 Nov 12;5:123-33.

Khan HA, Baig FK, Mehboob R. Nosocomial infections: Epidemiology, prevention, control and surveillance. Asian Pacific Journal of Tropical Biomedicine. 2017 May 1;7(5):478-82.

Afzal S, Mehboob R, Bukhari MH. Hypertesion and Low Birth Weight Babies in Females Sterilized with Quinacrine in Faisalabad from 1995 to 2005. Annals of King Edward Medical University. 2013;19(4):317-.

Uddin RM, Babar ME, Nadeem A, Hussain T, Ahmad S, Munir S, Mehboob R, Ahmad FJ. Genetic analysis of prolactin gene in Pakistani cattle. Molecular biology reports. 2013 Oct;40:5685-9.

Mehboob R, Munir M, Azeem A, Naeem S, Tariq MA, Ahmad FJ. Low platelet count associated with dengue hemorrhagic fever. International Journal of Advances in Chemistry (IJAC). 2013 Nov;1(1):29-34.

Parveen S, Mehboob R, Khan AA, Bukhari MH, Ahmad FJ. Novel strategy to diagnose and grade hepatocellular carcinoma.

MUNIR M, MEHBOOB R, NAEEM S, SALMAN M, AHMED S, QURESHI IH, CHEEMA TM, LAEEQ A, SULTAN A, CHOUDHRY N, KHAN AA. Serotype distribution and demographics of dengue patients in a tertiary hospital of Lahore, Pakistan during the 2011 epidemic. Walailak Journal of Science and Technology (WJST). 2013 Mar 14;10(3):305-14.

Khan AA, Bukhari MH, Mehboob R. Association of retinoblastoma with clinical and histopathological risk factors.

Sajid MI, Mehboob R, Ahmed S, Jamshaid M, Majeed I, Ahmed F. et al. Association of Serum Thyroid Hormones and Serum Leptin with Body Mass Index

Khan AA, Mehboob R, Bukhari MH. Prognostic significance of retinoblastoma gene mutation in retinoblastoma eye with respect to pathological risk factors.

Afzal S and Mehboob R. Adverse fetal outcomes after quinacrine sterilization failure in Faisalabad, Pakistan European Journal of Developing Country Studies. 2013; 14: 1-6

Get Report